People have lived in Puebla for thousands of years. In the Tehuacán Valley, folks found the world's oldest corn around 1500 BCE. Stone tools from 6500 BCE show early hunters and gatherers.
By 900 BCE, they grew corn, beans, squash, chilies, and cotton. City-states popped up, like in Cholula.
Groups like the Mixtecs, Popolocas, Nahuas, Totonacs, and Otomi built homes and traded. In the 1400s, powerful Aztecs ruled much of Puebla until new explorers arrived.